型号:
产品价格:电议      采购度:1599      原产地:美洲
发布时间:2021/8/2 16:03:01 所属地区:上海 上海市
简要描述:
Diquafosol tetrasodium 是一种P2Y2受体激动剂,可刺激眼睛表面的液体和粘蛋白分泌,用于干眼病的研究。
标签:INS365
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CAS No. : 211427-08-6
MCE 站:Diquafosol tetrasodium
产品活性:Diquafosol tetrasodium 是一种P2Y2受体激动剂,可刺激眼睛表面的液体和粘蛋白分泌,用于干眼病的研究。
研究领域:GPCR/G Protein
作用靶点:P2Y Receptor
In Vitro: Cell viability significantly decreased after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control.
In Vivo: In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, based on increases in tear fluid secretion, corneal epithelial resistance, and release of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of diquafosol tetrasodium as low as 1%. INS365 significantly suppresses corneal damage at concentrations of more than 0.1% w/v.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Nucleotide Compound Library | Anti-COVID-19 Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Ticagrelor | Clopidogrel hydrogen sulfate | Uridine 5′-diphosphoglucose disodium salt | YM-254890 | MRS 2578 | Uridine-5'-diphosphate disodium salt | BPTU | Cangrelor tetrasodium | AZD1283 | Prasugrel hydrochloride | 2-Methylthioadenosine diphosphate trisodium | Adenosine 2',5'-diphosphate sodium | MRS2279 | MRS2500 tetraammonium | MRS2698 | NF157 | NF546 | trans-R-138727MP | Denufosol tetrasodium | TAK-024
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更新时间:2024/1/2 10:17:29
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