MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

(±)-Ibipinabant

CAS No. : 362519-49-1

MCE 站：(±)-Ibipinabant

产品活性：(±)-Ibipinabant ((±)-SLV319) 是SLV319的消旋体。(±)-Ibipinabant ((±)-SLV319) 是有效选择性的大麻素-1 (CB-1) 受体拮抗剂，IC₅₀值为22 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Cannabinoid Receptor

In Vitro: Cannabinoid receptor 1 (CB1R) antagonists appear to be promising drugs for the treatment of obesity, however, serious side effects have hampered their clinical application. Ibipinabant is a new, potent [K_i (CB1)=7.8 nM] and selective [K_i (CB2)=7.943 nM] CB1 antagonist [pA2 for arachidonic acid release in CHO cells=9.9] with in vitro pharmacological characteristics similar to rimonabant including inverse agonism and brain penetrance.

In Vivo: (±)-Ibipinabant ((±)-SLV319) (3 mg/kg) reduces unfasted glucose to a significantly greater degree than rimonabant at the same dose on days 17, 28 and 38. Chronic treatment with (±)-Ibipinabant ((±)-SLV319) significantly attenuates the progression of diabetes in ZDF rats, blunting the increase in blood glucose and HbA1c over time. Ibipinabant also reduces the hyperinsulinemia apparent at 6-8 weeks of age and attenuates the dramatic reduction in insulin levels observed 1-2 weeks later.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Diabetes Related Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  WIN 55,212-2 Mesylate  |  Rimonabant Hydrochloride  |  AM251  |  JD-5037  |  SR144528  |  2-Arachidonoylglycerol  |  6-Iodopravadoline  |  Pregnenolone  |  β-Caryophyllene  |  Olivetol  |  Olorinab  |  N-Oleoyl glycine  |  Org 27569  |  CB1 antagonist 2  |  TM38837  |  Yangonin  |  Taranabant ((1R,2R)stereoisomer)  |  MDA 19  |  BML-190  |  2-Palmitoylglycerol  |  AM281  |  BAY 38-7271  |  CB2R PAM  |  Hemopressin (human, mouse)  |  Hemopressin(rat)

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。