MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AZD5153 6-Hydroxy-2-naphthoic acid

CAS No. : 1869912-40-2

MCE 站：AZD5153 6-Hydroxy-2-naphthoic acid

产品活性：AZD5153 6-Hydroxy-2-naphthoic acid是AZD5153的6-羟基-2-萘甲酸盐形式。AZD5153是一种有效选择性，有口服活性的BET/BRD4溴结构域抑制剂; 干扰BRD4的IC₅₀值为1.7nM。

研究领域：Epigenetics

作用靶点：Epigenetic Reader Domain

In Vitro: AZD5153 demonstrates a remarkable enhancement in potency for the displacement of full-length BRD4 relative to BD1, with IC₅₀ values of 5.0 nM and 1.6 μM, respectively. AZD5153 potently disrupts BRD4 foci in U2OS cells with an IC₅₀ value of 1.7 nM. AZD5153 efficiently down-regulates MYC protein levels across the cell line panel irrespective of their sensitivity to AZD5153.

In Vivo: Administration of AZD5153 leads to tumor stasis or regression in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B-cell lymphoma. AZD5153 treatment markedly impacts transcriptional programs of MYC, E2F, and mTOR.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Reprogramming Compound Library  |  Orally Active Compound Library  |  Anti-Blood Cancer Compound Library  |  A-485  |  Curcumin  |  Birabresib  |  C646  |  JQ-1 (carboxylic acid)  |  Anacardic Acid  |  I-BET151  |  SGC-CBP30  |  MG 149  |  KG-501  |  A-366  |  NSC 228155  |  CPI-203  |  PFI-1  |  IACS-9571 hydrochloride  |  ACBI1  |  GSK2801  |  MI-3  |  (+)-JQ1 PA  |  SGC-iMLLT  |  PF-CBP1 hydrochloride  |  Bromosporine  |  EML 425  |  MS436  |  GSK1379725A  |  GSK6853  |  HJB97  |  MS31 trihydrochloride  |  MS645  |  PROTAC BRD9 Degrader-1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。