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GPR120 Agonist 3

CAS No. : 1599477-75-4

MCE 站：GPR120 Agonist 3

产品活性：GPR120 Agonist 3 是选择性的Gpr120激动剂，logEC₅₀值为 ?7.62。

研究领域：GPCR/G Protein

作用靶点：GPR120

In Vitro: GPR120 Agonist 3 is fully selective for Gpr120 (logEC50=?7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP₃ production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC₅₀s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation .

In Vivo: GPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  TUG-891  |  GSK137647A  |  Ginsenoside Rb2  |  GPR120 Agonist 2  |  AH-7614  |  GPR120 modulator 2  |  Grifolic acid  |  MEDICA16

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