型号:
产品价格:电议      采购度:1623      原产地:美洲
发布时间:2021/8/2 16:26:32 所属地区:上海 上海市
简要描述:
TPI-1是SHP-1的抑制剂;抑制重组SHP-1的IC50值为40 nM。
标签:tpi1
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CAS No. : 79756-69-7
MCE 站:TPI-1
产品活性:TPI-1是SHP-1的抑制剂;抑制重组SHP-1的IC50值为40 nM。
研究领域:Metabolic Enzyme/Protease
作用靶点:Phosphatase
In Vitro: SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood.
In Vivo: TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.
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更新时间:2024/6/12 13:03:18
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