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Iberdomide

CAS No. : 1323403-33-3

MCE 站：Iberdomide

产品活性：Iberdomide (CC-220) 是 cereblon (CRBN) 调节剂，IC₅₀ 值为 60 nM。

研究领域：PROTAC  |  Apoptosis

作用靶点：Ligand for E3 Ligase  |  Apoptosis

In Vitro: Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC₅₀s of 1 nM and 0.5 nM .

In Vivo: Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM).

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