MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Paprotrain

CAS No. : 57046-73-8

MCE 站：Paprotrain

产品活性：Paprotrain是可渗透细胞的kinesin MKLP-2 的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC₅₀ 值为 1.35 μM，K_i 值为 3.36 μM，同时对 DYRK1A 有中等的抑制作用，IC₅₀值为 5.5 μM。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Kinesin

In Vitro: Paprotrain has been screened on a panel of CNS kinases. While inactive (IC₅₀ >10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC₅₀=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Aging Compound Library  |  Cytoskeleton Compound Library  |  Kif15-IN-1  |  Monastrol  |  AZ82  |  Litronesib  |  SB-743921 hydrochloride  |  CW-069  |  PF-2771  |  GW406108X  |  Dimethylenastron  |  Kif15-IN-2  |  Eg5 Inhibitor V, trans-24  |  BRD9876

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。