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STAT5-IN-1

CAS No. : 285986-31-4

MCE 站：STAT5-IN-1

产品活性：STAT5-IN-1是 STAT5 的抑制剂，对 STAT5β 亚型的 IC₅₀ 值为 47 μM。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：STAT

In Vitro: The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 ?M). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Stattic  |  AG490  |  Fludarabine  |  AS1517499  |  Niclosamide  |  Artesunate  |  Homoharringtonine  |  TPCA-1  |  Colivelin TFA  |  Cryptotanshinone  |  Napabucasin  |  Pimozide  |  C188-9  |  Scutellarin  |  BP-1-102  |  Cucurbitacin I  |  Saikosaponin D  |  Fraxinellone  |  Nifuroxazide  |  STAT3-IN-1  |  Alantolactone  |  Atractylenolide I  |  Dihydroisotanshinone I  |  FLLL32  |  HO-3867  |  Mogrol  |  Diosgenin  |  Garcinone D  |  HJC0152 hydrochloride  |  STAT3-IN-3

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