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Belotecan hydrochloride

CAS No. : 213819-48-8

MCE 站：Belotecan hydrochloride

产品活性：Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶 I (Topoisomerase I) 抑制剂，是一种合成的喜树碱衍生物。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC₅₀ values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC₅₀ values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.

In Vivo: Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Doxorubicin hydrochloride  |  Etoposide  |  Irinotecan  |  SN-38  |  Camptothecin  |  Topotecan Hydrochloride  |  Epirubicin hydrochloride  |  Daunorubicin hydrochloride  |  Exatecan mesylate  |  Suramin sodium salt  |  Berberine chloride  |  Mitoxantrone  |  Betulinic acid  |  EIDD-1931  |  Idarubicin hydrochloride  |  Aldoxorubicin  |  Banoxantrone dihydrochloride  |  β-Lapachone  |  Teniposide  |  Hycanthone  |  Pirarubicin  |  Bisantrene  |  Aclacinomycin A hydrochloride  |  Amsacrine

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