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产品价格:电议      采购度:1598      原产地:美洲
发布时间:2021/8/2 17:27:42 所属地区:上海 上海市
简要描述:
L-4-Oxalysine hydrochloride是从中国的链霉菌培养基中分离的天然物质,具有抗癌活性。
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CAS No. : 118021-35-5
MCE 站:L-4-Oxalysine hydrochloride
产品活性:L-4-Oxalysine hydrochloride是从中国的链霉菌培养基中分离的天然物质,具有抗癌活性。
研究领域:Anti-infection
作用靶点:Fungal
In Vitro: Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.
In Vivo: Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma.
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更新时间:2024/1/2 10:17:29
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