MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

KRN4884

CAS No. : 152802-84-1

MCE 站：KRN4884

产品活性：KRN4884 是一种 K⁺ 通道开放剂。在细胞内 ATP (1 mM) 存在下，KRN4884 (0.1-3 μM) 激活 K_ATP通道 (EC₅₀=0.55 μM), 这种作用存在浓度依赖性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: KRN4884 (0.3 μM) shifts the concentration-response relationship for ATP-induced K_ATP channel inhibition to the right and slightly upward direction without altering the slope. After either the spontaneous or Ca²⁺-induced channel rundown, KRN4884 (1 and 3 μM) partially restores the K_ATP channel activity. Furthermore, the effect of KRN4884 is augmented by the presence of uridine 5′-diphosphate (3 mM). KRN4884 activates cardiac K_ATP channels through not only decreasing the sensitivity of the channel to ATP but also directly stimulating the opening of the channel. KRN4884 (0.3 and 3 μM) increases the outward current in a concentration-dependent manner, and the unitary current amplitudes are similar to that of K_ATP channels in the ATP-free solution.

In Vivo: The effects of KRN4884, a novel pyridinecarboxamidine type K_ATP channel opener, on serum triglyceride levels are investigated in Sprague-Dawley rats. Oral administration of KRN4884 (3 mg/kg) for 10 days causes a significant reduction in serum triglyceride levels, which is comparable to that of Clofibrate (160 mg/kg). Reduction in serum triglyceride levels by KRN4884 and Clofibrate are accompanied by a reduction in triglyceride levels both in chylomicron and in very low density lipoprotein. KRN4884 treatment does not affect serum concentrations of total cholesterol and phospholipid, but increases free fatty acid levels. Rats receiving KRN4884 exhibite an increase in lipoprotein lipase (LPL) activity both in adipose tissue and in skeletal muscle.

相关产品：Nigericin sodium salt  |  BAPTA-AM  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Glibenclamide  |  SCH-23390 hydrochloride  |  Tetrandrine  |  Amiodarone hydrochloride  |  TRAM-34  |  Ifenprodil tartrate  |  Minoxidil  |  Diazoxide  |  20(S)-Ginsenoside Rg3  |  Senicapoc  |  Tannic acid  |  DCPIB  |  Astemizole  |  Ketanserin  |  Quinine  |  E-4031  |  Terfenadine  |  Hydrochlorothiazide  |  GW9508  |  Daurisoline  |  Nicorandil  |  Dofetilide  |  Pinacidil monohydrate  |  ML277  |  Tolbutamide  |  Almitrine mesylate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。