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Tropodifene

CAS No. : 15790-02-0

MCE 站：Tropodifene

产品活性：Tropodifene (Tropaphen) 是α-肾上腺素能受体 (α-Adrenergic receptor) 抑制剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vivo: Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits.

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