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产品价格:电议      采购度:1602      原产地:美洲
发布时间:2021/8/2 19:11:18 所属地区:上海 上海市
简要描述:
Ferroquine (Ferrochloroquine),是 Chloroquine 的二茂铁基类似物,是一种抗疟疾剂。Ferroquine 通过诱导氧化应激和随后的膜破坏而对疟原虫表现出杀虫作用。
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CAS No. : 185055-67-8
MCE 站:Ferroquine
产品活性:Ferroquine (Ferrochloroquine),是 Chloroquine 的二茂铁基类似物,是一种抗疟疾剂。Ferroquine 通过诱导氧化应激和随后的膜破坏而对疟原虫表现出杀虫作用。
研究领域:Anti-infection
作用靶点:Parasite
In Vitro: Ferroquine shows cytotoxicity against non-cancerous MRC-5 and HeLa cancer cells with IC50 values of 24.4 ?M and 16.8 ?M, respectively.
24?hours post-incubation all newly transformed schistosomula (NTS) exposed to 33.3??M Ferroquine shows strongly reduced viabilities.
In Vivo: Treatment of mice with 200 and 800?mg/kg Ferroquine, shows low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800?mg/kg Ferroquine died within 24?hours post-treatment. No activity is observed treating mice with RQ at 200?mg/kg. Finally, a total worm burden reduction of 17.3% is observed following treatment with FQ-OH. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. For comparison, at 200?mg/kg mefloquine (MQ) achieves a much higher worm burden reduction of 72.3% in S. mansoni-infected mice. A higher effect against female adult S. mansoni is also observed in MQ treated mice pointing to a sex-specific interference of these drugs with the target. Furthermore, in one of the FQ-OH treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and FQ-OH show weak antischistosomal activity in vivo.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Chloroquine | Hydroxychloroquine sulfate | Ivermectin | Kaempferol | Metronidazole | Dihydroartemisinin | Niclosamide | Suramin sodium salt | Artesunate | Artemisinin | Quinidine | Halofuginone | Miransertib | Mefloquine hydrochloride | Quinacrine dihydrochloride | Sanguinarine chloride | Amodiaquine dihydrochloride dihydrate | Ascomycin | Mebendazole | Atovaquone | Methylene Blue | Bithionol | Diminazene aceturate | Okadaic acid | Quinine | Urethane | Levamisole hydrochloride | Osthole | Fenbendazole
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更新时间:2024/1/2 10:17:29
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