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Ro 10-5824 dihydrochloride

CAS No. : 189744-94-3

MCE 站：Ro 10-5824 dihydrochloride

产品活性：Ro 10-5824 dihydrochloride 是一种选择性的 dopamine D4 受体 部分激动剂，K_i 值为 5.2 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vitro: RO-10-5824 shows high affinity binding with a K_i=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates ³⁵S-GTPγS binding with an EC₅₀ value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level.

In Vivo: Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.

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