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ST034307

CAS No. : 133406-29-8

MCE 站：ST034307

产品活性：ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC₅₀ 值为 2.3 μM。

研究领域：GPCR/G Protein

作用靶点：Adenylate Cyclase

In Vitro: ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca²⁺/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.

In Vivo: ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E₅₀) value for analgesia of 0.28 μg in the mouse pain model.

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