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L755507

CAS No. : 159182-43-1

MCE 站：L755507

产品活性：L755507 是一个有效的, 选择性强的 β₃-AR 激动剂, 其 IC₅₀ 值为 35 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Cell Cycle/DNA Damage

作用靶点：Adrenergic Receptor  |  CRISPR/Cas9

In Vitro: L755507 causes a robust concentration-dependent increase in cAMP accumulation (pEC₅₀ values of 8.5 and 12.3, respectively). Maximal cAMP accumulation with zinterol and L755507 is increased after pretreatment with pertussis toxin. In contrast to cAMP, zinterol, L755507 and L748337 increase phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with very high potency (pEC₅₀ values of 10.9, 11.7 and 11.6). L755507 and Scr7 do not reduce cell viability significantly. Scr7 does not affect cell cycle distribution in a range of 10 to 200?μM. L755507 significantly decreases the proportion of cells in the G2/M phase at 10?μM or 40?μM and increases the S-phase cells at 10?μM compare with the DMSO-treated cells.

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