型号:
产品价格:电议      采购度:1592      原产地:美洲
发布时间:2021/8/2 19:47:43 所属地区:上海 上海市
简要描述:
Cholestyramine (Colestyramine) 是胆汁酸结合树脂,它可以抑制肠胆汁酸吸收导致增加粪便胆汁酸排泄,进而又增加胆固醇胆汁酸合成。
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CAS No. : 11041-12-6
MCE 站:Cholestyramine
产品活性:Cholestyramine (Colestyramine) 是胆汁酸结合树脂,它可以抑制肠胆汁酸吸收导致增加粪便胆汁酸排泄,进而又增加胆固醇胆汁酸合成。
研究领域:Others
作用靶点:Others
In Vivo: Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. Results reveal that GSPE treatment alone, and co-administration with Cholestyramine (Colestyramine), regulate BA, cholesterol and TG metabolism differently compare to Cholestyramine administration alone. Notably, GSPE decreases intestinal apical sodium-dependent bile acid transporter (Asbt) gene expression, while Cholestyramine significantly induces expression. Administration with GSPE or Cholestyramine robustly induces hepatic BA biosynthetic gene expression, especially cholesterol 7α-hydroxylase (Cyp7a1), compare to control, while co-administration further enhances expression. Treatment with Cholestyramine induces both intestinal and hepatic cholesterologenic gene expression, while co-administration with GSPE attenuates the Cholestyramine-inducing increase in the liver but not in the intestine. Cholestyramine also induces hepatic lipogenic gene expression, which is attenuated by co-administration with GSPE.
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更新时间:2024/1/2 10:17:44
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