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产品价格:电议      采购度:1637      原产地:美洲
发布时间:2021/8/2 19:54:28 所属地区:上海 上海市
简要描述:
3-TYP 是一种选择性的 SIRT3 抑制剂,IC50 值为 16 nM, 比对 SIRT1 和 SIRT2 的选择性强,IC50 值分别为 88 nM 和 92 nM。
标签:3typ
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CAS No. : 120241-79-4
MCE 站:3-TYP
产品活性:3-TYP 是一种选择性的 SIRT3 抑制剂,IC50 值为 16 nM, 比对 SIRT1 和 SIRT2 的选择性强,IC50 值分别为 88 nM 和 92 nM。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:Sirtuin
In Vitro: 3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2?? production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.
In Vivo: 3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Resveratrol | Selisistat | Nicotinamide | Nicotinamide riboside chloride | Suramin sodium salt | OSS_128167 | Fisetin | UBCS039 | Sirtinol | CAY10602 | AGK2 | AK-7 | SIRT5 inhibitor 1 | Cambinol | MC3482 | Ganoderic acid D | PROTAC Sirt2 Degrader-1 | SRT 2183 | Dihydrocoumarin | Ginkgolide C | Inauhzin | SIRT-IN-3 | JFD00244 | Gardenia yellow | Agrimol B | Sirtuin modulator 1 | Ophiopogonin D' | Scopolin | SirReal2
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更新时间:2024/1/2 10:17:44
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