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Blarcamesine hydrochloride

CAS No. : 195615-84-0

MCE 站：Blarcamesine hydrochloride

产品活性：Blarcamesine hydrochloride (AVex-73 hydrochloride) 是一个 Sigma-1 受体激动剂，其 IC₅₀ 值为 860 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Sigma Receptor

In Vivo: The pre-administration of Blarcamesine (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1?mg/kg. One day after injections, the significant Aβ_25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1?mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser⁹ phosphorylation induced by the peptide at 0.3 and 1?mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ_25-35-induced increase in Aβ_1-42 content, with a significant effect at the highest dose tested.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Neuroprotective Compound Library  |  PRE-084 hydrochloride  |  BD-1047 dihydrobromide  |  Dimemorfan phosphate  |  Siramesine hydrochloride  |  Cutamesine dihydrochloride  |  Glycerol phenylbutyrate  |  BD1063 dhydrochloride  |  SR-31747  |  Sigma-2 receptor antagonist 1  |  Blonanserin  |  Roluperidone  |  Ditolylguanidine  |  OPC-14523 hydrochloride  |  Panamesine  |  4-IBP  |  DuP 734  |  E1R  |  KB-5492 anhydrous  |  PD 144418  |  (±)-Vesamicol hydrochloride  |  Blarcamesine

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