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Zofenopril

CAS No. : 81872-10-8

MCE 站：Zofenopril

产品活性：Zofenopril 是一个 angiotensin-converting enzyme (ACE) 抑制剂，其 IC₅₀ 值为 81 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Angiotensin-converting Enzyme (ACE)

In Vitro: Kinetic analyses demonstrate that enalapril inhibits the uptake of GlySar in a competitive manner (K_i approximately 6 mM). Fosinopril and Zofenopril have the greatest inhibitory potency (IC₅₀ values of 55 and 81μM, respectively) while the other ACE inhibitors exhibit low-affinity interactions with the renal peptide transporter.

In Vivo: Zofenopril, a sulphydrylic compound, at doses higher than 70 mg/kg i.p. produces significant protection (i.e. at 70 mg/kg, P=0.044, F=2.17, d.f.=18; at higher concentration P<0.05) against the tonic phase of the audiogenic seizure response. Pretreatment with Zofenopril (15 mg/kg, i.p.) is able to produce a consistent shift to the left of the dose-response curves and a significant reduction of ED₅₀ values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity.

相关产品：MLN-4760  |  Angiotensin (1-7)  |  Captopril  |  Enalapril maleate  |  Diminazene aceturate  |  Lisinopril dihydrate  |  Perindopril erbumine  |  Fosinopril sodium  |  Sinapinic acid  |  Benazepril hydrochloride  |  Omapatrilat  |  Quinapril hydrochloride  |  Ramipril  |  Moexipril hydrochloride  |  Phosphoramidon Disodium  |  Deserpidine  |  Enalaprilat dihydrate  |  Cilazapril monohydrate  |  Resorcinolnaphthalein  |  Trandolapril  |  Delapril hydrochloride  |  Imidapril hydrochloride  |  Zofenopril calcium  |  H-Ile-Pro-Pro-OH hydrochloride  |  Alamandine  |  N-Acetyl-Ser-Asp-Lys-Pro TFA  |  Temocapril hydrochloride  |  BML-111

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