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K-80003

CAS No. : 1292821-90-9

MCE 站：K-80003

产品活性：K-80003 有效抑制 tRXRα 依赖性的 Akt 激活和肿瘤细胞生长。

研究领域：PI3K/Akt/mTOR

作用靶点：Akt

In Vitro: When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.

In Vivo: K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Honokiol  |  GSK-690693  |  Artemisinin  |  Oridonin  |  Perifosine  |  Guggulsterone  |  Miransertib  |  Triciribine  |  Recilisib  |  SU6656  |  Isobavachalcone  |  Scutellarin  |  Deguelin  |  Miltefosine  |  A-674563 hydrochloride  |  α-Linolenic acid  |  YS-49  |  Urolithin B  |  Polyphyllin I  |  Pachymic acid  |  3CAI  |  1,3-Dicaffeoylquinic acid  |  Esculetin  |  Cyclovirobuxine D  |  Licochalcone E  |  SC66  |  Akt1 and Akt2-IN-1  |  Arnicolide D  |  Loureirin A

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