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SN 6

CAS No. : 415697-08-4

MCE 站：SN 6

产品活性：SN 6 是一种选择性的 NCX 抑制剂，可抑制 NCX1，NCX2 和 NCX3 对 ⁴⁵Ca²⁺ 的吸收，IC₅₀ 值分别为 2.9，16 和 8.6 μM。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Na+/Ca2+ Exchanger

In Vitro: SN 6 is a selective Na⁺/Ca²⁺ exchanger inhibitor, which inhibits the initial rate of ⁴⁵Ca²⁺ uptake into NCX1, NCX2, and NCX3 transfectants with IC₅₀ values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC₅₀ of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na⁺_i-dependent ⁴⁵Ca²⁺ uptake into Na⁺-loaded sarcolemmal vesicles in a dose dependent manner (IC₅₀, 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants. SN 6 (1-30 μM) suppresses the bidirectional outward and inward I_NCX in a concentration-dependent manner, with IC₅₀ values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (I_NCX) in a [Na⁺]i concentration-dependent manner, with IC₅₀ values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na⁺]i, respectively. SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC₅₀ value of 0.63 ± 0.15 μM in NCX1 transfectants.

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