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PKM2-IN-1

CAS No. : 94164-88-2

MCE 站：PKM2-IN-1

产品活性：PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂，其 IC₅₀ 值为 2.95 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Pyruvate Kinase

In Vitro: PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC₅₀ values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Glycolysis Compound Library  |  Shikonin

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