MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Aminooxyacetic acid hemihydrochloride

CAS No. : 2921-14-4

MCE 站：Aminooxyacetic acid hemihydrochloride

产品活性：Aminooxyacetic acid hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vitro: Aminooxyacetic acid hemihydrochloride (AOAA) dose-dependently decreases the survival of C6 glioma cells. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase. Aminooxyacetic acid hemihydrochloride treatment leads to an obvious decrease in the number of the cells in the phase of cell division. Aminooxyacetic acid hemihydrochloride significantly increases the percentage of the cells in both early-stage apoptosis and necrosis. Treatment of the cells with 1?mM or 5?mM Aminooxyacetic acid hemihydrochloride leads to decreased levels of aging of the cells. Glutamine-dependent cell lines show greater inhibition of cell growth by Aminooxyacetic acid hemihydrochloride (AOA) compare with cells that are less glutamine dependent.

In Vivo: The accumulation of GABA in cerebellum and whole brain is initially very rapid, being significantly increased already 5 min after the injection of Aminooxyacetic acid hemihydrochloride (AOAA). The rapid initial accumulation becomes gradually slower and maximal levels (400 to 600 % of the control levels) are reached 2 to 6 h after Aminooxyacetic acid hemihydrochloride. Still 24 h after Aminooxyacetic acid hemihydrochloride the GABA levels are elevated by about 250%. From 2 to 6 h after Aminooxyacetic acid hemihydrochloride the convulsions are completely blocked. Twenty four hours after Aminooxyacetic acid hemihydrochloride the convulsions are almost identical to the controls.

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  (+)-Bicuculline  |  Gabazine  |  Riluzole  |  γ-Aminobutyric acid  |  Picrotoxin  |  Propofol  |  Vigabatrin  |  (R)-Baclofen  |  CGP52432  |  Furosemide  |  Etomidate  |  Flumazenil  |  Dihydroergotoxine mesylate  |  Ginkgolide A  |  Methionine  |  Emamectin Benzoate  |  Etifoxine  |  Isoguvacine hydrochloride  |  Jujuboside A  |  Topiramate  |  Lotilaner  |  (-)-Securinine  |  alpha-Asarone  |  Clomethiazole  |  Acamprosate calcium  |  DMCM hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。