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Desipramine hydrochloride

CAS No. : 58-28-6

MCE 站：Desipramine hydrochloride

产品活性：Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂，其 K_i 值分别为 4, 61 和 78,720 nM。

研究领域：Neuronal Signaling

作用靶点：Dopamine Transporter  |  Serotonin Transporter

In Vivo: Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of ³H-nisoxetine to the NET in preparations of cerebral cortex (F_(3,16)=4.33, p<0.05) and hippocampus (F_(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay).

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