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S 3304

CAS No. : 203640-27-1

MCE 站：S 3304

产品活性：S 3304 是一个新型的基质金属蛋白酶 (MMP) 抑制剂, 且对 MMP-2 和 MMP-9 有特异的抑制活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vitro: S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors.

In Vivo: In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen.

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