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Tinoridine hydrochloride

CAS No. : 25913-34-2

MCE 站：Tinoridine hydrochloride

产品活性：Tinoridine hydrochloride是一种非甾体抗炎药，也具有强效的自由基清除和抗过氧化物活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Glutathione Peroxidase

In Vitro: Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe²⁺, in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe²⁺, but its oxidation is slow in the absence of Fe²⁺ and almost completely inhibited by catalase. Tinoridine is also oxidized by H₂O₂-Fe²⁺ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical.

In Vivo: CCl₄ aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl₄-induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed.

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