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Pifithrin-μ

CAS No. : 64984-31-2

MCE 站：Pifithrin-μ

产品活性：Pifithrin-μ 是一种 p53 和 HSP70 的抑制剂，具有抗肿瘤和神经保护作用。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage  |  Autophagy

作用靶点：MDM-2/p53  |  HSP  |  Autophagy

In Vitro: Pifithrin-μ (10 μM) is a p53 inhibitor, which inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation, activity of caspases 2, 8, 9 and 10 in a cell-free system, or NF-κB-dependent transcription. Pifithrin-μ (PES) time- and dose-dependently reduces viability in A549 cells, with IC₅₀s of 44.9 and 25.7 ?M at 24 h and 48 h. Pifithrin-μ (20 μM) suppresses the cell migration, induces cell cycle arrest and cell apoptosis in A549 and H460 cells. Pifithrin-μ (10 or 20 ?M) inhibits activities of AKT, ERK, and Hsp70 in A549 and H460 cells. Pifithrin-μ (20 ?M) sensitizes A549 and H460 cell lines to TRAIL-induced cell proliferation inhibition and apoptosis.

In Vivo: Pifithrin-μ (40 mg/kg, i.p.) shows no protective effect against doses of radiation that cause gastrointestinal syndrome in mice. Pifithrin-μ (PES, 10 mg/kg) shows antitumor effect in mice bearing A549 cells. Pifithrin-μ exhibits neuroprotective effect with the P53-inhibitor pifithrin-μ after cardiac arrest in a rodent model.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Tamoxifen  |  Tanespimycin  |  Nutlin-3a  |  Pifithrin-α hydrobromide  |  Geldanamycin  |  Palmitic acid  |  Eprenetapopt  |  Rocaglamide  |  VER-155008  |  Arimoclomol maleate  |  Amifostine  |  PU-WS13  |  RITA  |  MKT-077  |  KNK437  |  KRIBB11  |  MI-773  |  Paeoniflorin  |  Pifithrin-α, p-Nitro, Cyclic  |  Retaspimycin Hydrochloride  |  TRC051384  |  ML346  |  NSC319726  |  Radicicol  |  Amifostine thiol dihydrochloride  |  Teprenone

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