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Aftin-4

CAS No. : 866893-90-5

MCE 站：Aftin-4

产品活性：Aftin-4 是 β-淀粉样蛋白₄₂ (Aβ₄₂) 的诱导剂。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: Aftin-4 selectively and potently increases Aβ_1-42 in N2a cells, primary neurons, and brain lysates, with an EC₅₀ value around 30 μM.

In Vivo: Aftin-4 increases Aβ_1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ_1-40 or Aβ_1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ_1-42 content, up to +216% at the highest dose tested.

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