MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BETP

CAS No. : 1371569-69-5

MCE 站：BETP

产品活性：BETP 是一种胰高血糖素样肽 (GLP-1) 受体激动剂，对人和大鼠 GLP-1 受体的 EC₅₀ 值分别为 0.66 μM 和 0.755 μM。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: BETP is a GLP-1 receptor agonist, with EC₅₀s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively. BETP (Compound B) is inactive in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. BETP (1-10 μM) enhances insulin secretion in normal and diabetic human islets. In addition, BETP in combination with GLP-1 shows additive effects on increasing GLP-1 receptor signaling. BETP increases the potency of oxyntomodulin by 10-fold (EC₅₀ of 80 pM). GLP-1 does not change the potencies and efficacies of both oxyntomodulin and glucagon at the glucagon receptor. BETP (0-30 μM) increases the binding affinity of oxyntomodulin for the GLP-1 receptor.

In Vivo: BETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Diabetes Related Compound Library  |  Exendin-4  |  Liraglutide  |  Glucagon (1-29), bovine, human, porcine  |  Avexitide  |  Adomeglivant  |  GLP-1(7-37)  |  GLP-1(7-36), amide acetate  |  GLP-2(1-33)(human)  |  GRA Ex-25  |  NNC-0640  |  Cotadutide acetate  |  Glucagon-like peptide 1 (1-37), human TFA  |  Taspoglutide  |  GLP-1 moiety from Dulaglutide  |  Glucagon receptor antagonists-3  |  GLP-1(9-36)amide  |  GLP-2(3-33)  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  GLP-1(28-36)amide  |  GLP-1(32-36)amide  |  GLP-1R Antagonist 1  |  Glucagon receptor antagonists-1  |  GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  HAEGTFT

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。