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AZ7550 Mesylate

CAS No. :

MCE 站：AZ7550 Mesylate

产品活性：AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC₅₀ 为 1.6 μM。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease

作用靶点：EGFR  |  IGF-1R  |  Drug Metabolite

In Vitro: AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC₅₀s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI₅₀s of 19, 15, and 537 nM, respectively.

相关产品：Covalent Screening Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Differentiation Inducing Compound Library  |  Endocrinology Compound Library  |  Anti-Hepatitis C Virus Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Gefitinib  |  Trastuzumab  |  Erlotinib  |  Clozapine N-oxide  |  Cetuximab  |  AG490  |  Oseltamivir acid  |  Genistein  |  AG-1478  |  Urolithin A  |  Picropodophyllin  |  Pertuzumab  |  BI-4020  |  BMS-536924  |  NSC 228155  |  Pelitinib  |  Mubritinib  |  GSK1904529A  |  TX1-85-1  |  AZD-3463  |  NVP-TAE 226  |  Canertinib  |  Nortriptyline hydrochloride  |  AG1024  |  3-Methoxytyramine hydrochloride  |  Butein  |  PD168393

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