型号:
产品价格:电议      采购度:1610      原产地:美洲
发布时间:2021/8/3 15:00:09 所属地区:上海 上海市
简要描述:
LTX-401 是一种可靶向作用高尔基体 (Golgi apparatus) 的溶瘤氨基酸衍生物。
标签:ltx401
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MCE 站:LTX-401 dihydrochloride
产品活性:LTX-401 是一种可靶向作用高尔基体 (Golgi apparatus) 的溶瘤氨基酸衍生物。
研究领域:Others
作用靶点:Others
In Vitro: LTX-401, an oncolytic amino acid derivative, targets the Golgi apparatus. LTX-401 effectively reduces the viability of several tumor cell lines in vitro, with a similar degree of cytotoxicity against non-malignant cell lines such as HUV-EC-C endothelial cells, HaCat keratinocytes and MRC-5 fibroblasts. LTX-401 displays the highest cytotoxic activity against the human malignant melanoma cell line MDA-MB-435S (13.5 μM), and is least active against the human hepatocellular carcinoma cell line HEPG2 (35.4 μM). For the remaining cell lines, LTX-401 exhibits similar IC50 values, varying slightly within the range of 19-32 μM. No in vitro hemolytic activity against RBCs is observed using the same concentrations required for the induction of cell death in cancer cell lines. A 50% hemolysis is observed using higher concentrations of LTX-401 (400 μg/mL=1087 μM).
In Vivo: The majority (9/11) of the animals demonstrate a complete and lasting tumor regression after intratumoral treatment with LTX-401. Samples are collected from selected animals in the treatment group and control group on days 2 and 7 post-treatment with a single i.t injection. The immunolabelling of tumor tissue with anti-CD3 antibody reveals that a majority of the infiltrating cells are CD3+ T cells, whereas tumors injected with vehicle only exhibit tumors with a viable tumor tissue, with minimal necrosis and few lymphocytes.
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更新时间:2024/1/2 10:17:44
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