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S119-8

CAS No. : 443639-96-1

MCE 站：S119-8

产品活性：S119-8 是甲型和乙型流感病毒的广谱抑制剂，显示出对多种乙型流感病毒和耐奥司他韦的甲型流感病毒的抑制活性，但不抑制非流感病毒水疱性口炎 (VSV)。

研究领域：Anti-infection

作用靶点：Influenza Virus

In Vitro: S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC₅₀=1.43 μM) at non-toxic (CC₅₀=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC₅₀ of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC₅₀ of 8.42 μM.

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