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TES-991

CAS No. : 1883602-20-7

MCE 站：TES-991

产品活性：TES-991 是一种有效的、有选择性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶(ACMSD) 抑制剂，IC₅₀ 为3 nM。

研究领域：Others

作用靶点：Others

In Vitro: TES-991 (compounds 21) is able to significantly increase intracellular NAD⁺ levels, providing further proof of their mechanism of action. TES-991 shows an inhibition of cytochrome P450 2C19, suggesting a possible involvement of the 2H-tetrazole motif in this interaction.

In Vivo: After the intravenous administration of 0.5 mg/kg, TES-991 (compound 21) shows low blood clearance, with low volumes of distribution and halflives (t_1/2) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid.

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