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TAME hydrochloride

CAS No. : 1784-03-8

MCE 站：TAME hydrochloride

产品活性：TAME hydrochloride 是后期促进复合体 (APC/C 或 APC) 的抑制剂，它与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。

研究领域：Cell Cycle/DNA Damage

作用靶点：APC

In Vitro: The absence of APC substrates, TAME hydrochloride ejects Cdc20 from the APC by promoting Cdc20 auto-ubiquitination in its N-terminal region. Cyclin B1 antagonizes TAME hydrochloride's effect by promoting binding of free Cdc20 to the APC and suppressing Cdc20 auto-ubiquitination.
TAME hydrochloride stabilizes cyclin B1 in Xenopus extract by two mechanisms. First, it reduces the k_cat of the APC^Cdc20/cyclin B1 complex without affecting the K_m, slowing the initial ubiquitination of unmodified cyclin B1. Second, as cyclin B1 becomes ubiquitinated, it loses its ability to promote Cdc20 binding to the APC in the presence of TAME hydrochloride. As a result, cyclin B1 ubiquitination terminates before reaching the threshold necessary for proteolysis.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Apcin  |  TAME

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