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SB 204990

CAS No. : 154566-12-8

MCE 站：SB 204990

产品活性：SB 204990是ATP柠檬酸裂解酶 (ACLY) 的有效特异性抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：ATP Citrate Lyase

In Vitro: SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.

In Vivo: SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.

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