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Diprotin A TFA

CAS No. : 209248-71-5

MCE 站：Diprotin A TFA

产品活性：Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dipeptidyl Peptidase

In Vitro: Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.

In Vivo: In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Peptidomimetic Library  |  Diabetes Related Compound Library  |  Talabostat mesylate  |  Puromycin aminonucleoside  |  Vildagliptin  |  1G244  |  Nateglinide  |  Prolyl Endopeptidase Inhibitor 1  |  DPP-IV-IN-2  |  Prodipine hydrochloride  |  Saikogenin A  |  UAMC00039 dihydrochloride  |  2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one  |  Azaleatin  |  Diprotin A  |  Evogliptin tartrate  |  NDMC101  |  NVP-DPP728 dihydrochloride  |  DPP-IV-IN-1

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