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κ-Carrageenan

CAS No. : 11114-20-8

MCE 站：κ-Carrageenan

产品活性：κ-Carrageenan 是一种天然聚合物，主要存在于红色海藻中。κ-Carrageenan 是一种有效的药物载体，能在癌细胞中传递姜黄素，诱导凋亡。κ-Carrageenan 是一种潜在的炎症因子，可以放大现有的肠道炎症。

研究领域：Others

作用靶点：Others

In Vitro: κ-Car- Curcumin (Cur) (0-500 μg/mL; 24-72 hours) effectively involves in cancer cell growth inhibition at lower concentrations of 40 µg/mL.
The cytotoxicity of the Cur loaded κ-Car has a significantly high apoptotic activity in selected lung cancer cells of A549.
κ-Carrageenan (1-60 μg/mL; 0.5-24 hours) enhances LPS-induced IL-8 secretion in HT-29 cells.

In Vivo: κ-Carrageenan (1.7-41.7 mg/kg; p.o. for 1 week prior to C. freundii DBS100 treatment) can synergistically activate LPS-induced inflammatory through the Bcl10-NF-κB pathway, as indicated by its aggravation of C. freundii DBS100-induced colitis in mice.
κ-Carrageenan enhances the C. freundii DBS100-dependent induction of TLR4 ａnd NF-κB in the intestinal mucosa of infected mice.
κ-Carrageenan aggravated the TNBS-induced intestinal inflammation, ａnd such an effect could be associated with the oxidative stress ａnd activation of TLR4-NF-κB ａnd MAPK/ERK1/2 pathway

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