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Capsaicin (purity>99%)

CAS No. : 404-86-4

MCE 站：Capsaicin (purity>99%)

产品活性：Capsaicin (purity>99%) ((E)-Capsaicin (purity>99%)) 是辣椒中的活性成分，是一种 TRPV1 激动剂。Capsaicin (purity>99%) 具有减轻疼痛、抗氧化、抗炎、神经保护和抗癌作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Autophagy  |  Apoptosis

作用靶点：TRP Channel  |  Autophagy  |  Apoptosis

In Vitro: Capsaicin (50-300 µM; 24-72 hours) shows an augmented decrease in cell growth in a dose- ａnd time-dependent manner. The observed IC50 value is around 150 µM.
Capsaicin (50-300 µM; 24-72 hours) shows increase in cytosolic cytochrome c, activation of caspase 3 ａnd PARP (p85) levels, ａnd decreases anti-apoptotic Bcl-2 protein ａnd increases pro-apoptotic Bad/Bax expression.
Capsaicin increases the nuclear condensation, nuclear DNA fragmentation ａnd sub-G1 DNA content.
Capsaicin suppresses the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 ａnd D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 ａnd cdk-4.

In Vivo: Capsaicin suppresses the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax ａnd caspase-3.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Medicine Food Homology Compound Library  |  Orally Active Compound Library  |  Neuroprotective Compound Library  |  Alkaloids Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Y-27632 dihydrochloride  |  Paclitaxel  |  Acetylcysteine  |  Angiotensin II human  |  SP600125  |  Sorafenib  |  Staurosporine  |  5-Fluorouracil  |  Bortezomib  |  Trametinib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  MK-2206 dihydrochloride  |  Temozolomide  |  Verteporfin  |  Actinomycin D  |  Decitabine  |  Etoposide  |  BAY 11-7082  |  Pexidartinib  |  Mitomycin C  |  CCCP  |  DAPT  |  Ruxolitinib

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