MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

S-Adenosyl-L-methionine

CAS No. : 29908-03-0

MCE 站：S-Adenosyl-L-methionine

产品活性：S-Adenosyl-L-methionine (S-Adenosyl methionine) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，并可用于肝病和骨关节炎的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) ａnd then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine ａnd the sulfate (SO4) donated to other metabolic intermediates; ａnd 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form ａnd recycle methionine.
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis ａnd proliferation rates in rabbits.

In Vivo: Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels ａnd develop oxidative stress, steatohepatitis, ａnd hepatocellular carcinoma (HCC). However, injury ａnd HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health ａnd prevent injury ａnd HCC.

相关产品：Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Docetaxel  |  Estradiol  |  Melatonin  |  Nicotinamide  |  Cytarabine  |  Isoprenaline hydrochloride  |  Prostaglandin E2  |  Acetaminophen  |  (-)-Epigallocatechin Gallate  |  β-Nicotinamide mononucleotide  |  Calcitriol  |  Luteolin  |  Liothyronine  |  NAD+  |  Thymidine  |  Kaempferol  |  Palmitic acid  |  Docosahexaenoic Acid  |  L-Glutathione reduced  |  Genistein  |  Cyclopamine  |  Dimethyl fumarate  |  Progesterone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。