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Coronaridine

CAS No. : 467-77-6

MCE 站：Coronaridine

产品活性：Coronaridine，一种生物碱，通过降低 β-catenin 表达来抑制 wnt 信号传导通路。

研究领域：Stem Cell/Wnt

作用靶点：Wnt

In Vitro: Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC₅₀ values >40 μM. It agaisnt wnt-dependent cells with IC₅₀ values of 10.4, 11.6 ａnd 24.4 μM for SW480, HCT116 ａnd DLD1cells, respectively.
Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β－－catenin at Ser33, Ser37, ａnd Thr41 ａnd p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged.
In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC₃₀ value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner.
At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude ａnd rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 ａnd hα2β2γ2). The PAM activity of Catharanthine＇s are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM).

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