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Mahanine

CAS No. : 28360-49-8

MCE 站：Mahanine

产品活性：Mahanine 是一种咔唑类生物碱，具有多种生物学特性。Mahanine 是一种有效的抗癌试剂，可以对抗不同类型的癌细胞。Mahanine 具有抗利什曼原虫 (antileishmanial) 活性，可用于利什曼原虫感染治疗研究。

研究领域：Anti-infection

作用靶点：Parasite

In Vitro: Mahanine (0-50 µM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr ａnd 48 hr; the IC₅₀ values were 16.7±1.7 µM ａnd 11.5±0.8 µM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 ａnd 48 hr treatment with IC₅₀ values 40.3±2.2 µM ａnd 29.1±1.3 µM respectively.
Mahanine (5.0 ａnd 10 µM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% ａnd 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote .
Mahanine (25 µM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS.

In Vivo: Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, ａnd leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmania infection.

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