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Dehydrojuncusol

CAS No. : 117824-04-1

MCE 站：Dehydrojuncusol

产品活性：Dehydrojuncusol 是一种有效的丙型肝炎 (HCV) 病毒抑制剂，以丙型肝炎病毒 NS5A 为靶点，能够抑制带有抗 NS5A 直接作用抗病毒药物抗性突变的复制子的 RNA 复制。Dehydrojuncusol 可抑制 HCV 基因型 2a 的病毒感染 (EC₅₀=1.35 µM)。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：HCV  |  HCV Protease

In Vitro: Dehydrojuncusol (Huh-7 cells were infected with HCV in cell culture; 0-9.4 μM; 48 hours) inhibits HCV infection in a dose-dependent manner. Dehydrojuncusol inhibits HCV infection in Primary human hepatocytes (PHH).
The EC₅₀ of dehydrojuncusol is 1.35 µM when added continuously, 8.21 µM when added during inoculation, ａnd 1.53 µM when added postinoculation, confirming the major effect of the molecule at the postinoculation step. The toxicity of the compound on Huh-7 cells is also tested in parallel at different time points (24 h, 48 h, ａnd 72 h). The results shows that the CC₅₀ of Dehydrojuncusol Is approximately 75.6 µM, which is much higher than the active dose, yielding a selective index of 56.
Dehydrojuncusol is able to inhibit RNA replication of two frequent daclatasvir-resistant mutants (L31M or Y93H in NS5A). Dehydrojuncusol inhibits HCV RNA replication.

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