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23-epi-26-Deoxyactein

CAS No. : 501938-01-8

MCE 站：23-epi-26-Deoxyactein

产品活性：23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。

研究领域：Others

作用靶点：Others

In Vitro: 23-epi-26-Deoxyactein (DA :10 μM ａnd 20 μM) inhibits 3T3-L1 adipogenesis through down-regulating the expression of C/ebpα, C/ebpβ, ａnd Pparγ, which are the critical adipogenic transcription factors.
23-epi-26-Deoxyactein (DA) promotes mitochondrial biogenesis in pancreatic β-cells preventing methylglyoxal-induced oxidative cell damage ａnd protects osteoblasts against Antimycin A-induced cell damage.
23-epi-26-Deoxyactein (DA) inhibits growth of the MCF7 human breast cancer cells ａnd induces cell cycle arrest at G1 (IC₅₀ of 21μM).
23-epi-26-Deoxyactein (0.1-1 μM) protects osteoblasts against Antimycin A-induced cell damage.

In Vivo: 23-epi-26-Deoxyactein (DA: 5 ａnd 10 mg/kg/d) significantly lowers body weight gain, fat mass, ａnd liver weight in HFD-fed mice. 23-epi-26-Deoxyactein (DA) also reduces insulin resistance ａnd serum lipoprotein levels in HFD-fed mice.
23-epi-26-Deoxyactein (DA) promotes adipocyte lipolysis in mice through activating the AMPK signaling ａnd SIRT1-FOXO1 pathway.

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