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Emodin 6-O-β-D-glucoside

CAS No. : 34298-85-6

MCE 站：Emodin 6-O-β-D-glucoside

产品活性：Emodin-6-O-β-D-glucoside (Glucoemodin) 是从 Reynoutria japonica 中提取的一种活性化合物。Emodin-6-O-β-D-glucoside 具有明显的抗炎和屏障保护作用。Emodin-6-O-β-D-glucoside 可用于糖尿病并发症和动脉粥样硬化的研究。

研究领域：Others

作用靶点：Others

In Vitro: Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability.
Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 ａnd E-selectin ａnd results in decreased expression levels of high glucose-induced MCP-1 ａnd IL-8 mRNA.
Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.
Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation ａnd p65 NF-κB expression levels increase.

In Vivo: Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose.

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