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5-Hydroxy-2＇-deoxyuridine

CAS No. : 5168-36-5

MCE 站：5-Hydroxy-2＇-deoxyuridine

产品活性：5-Hydroxy-2＇-deoxyuridine (5-OHdU) 是一种 2＇-Deoxycytidine 的主要稳定氧化产物。5-Hydroxy-2＇-deoxyuridine 可以通过 DNA 聚合酶在体外掺入 DNA。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: To study the specificity of nucleotide incorporation opposite 5-hydroxypyrimidines in template DNA, 18- ａnd 45-member oligodeoxyribonucleotides, containing an internal 2＇-deoxy-5-hydroxyuridine (5-OHdU) in two different sequence contexts, were used. Translesion synthesis past 2＇-deoxy-5-hydroxyuridine (5-OHdU) in both oligonucleotides occurred, but pauses both opposite, ａnd one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 2＇-deoxy-5-hydroxyuridine (5-OHdU) in the template is sequence context dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 2＇-deoxy-5-hydroxyuridine (5-OHdU). However in a second sequence context, dC is the predominant base incorporated opposite 2＇-deoxy-5-hydroxyuridine (5-OHdU). In that same sequence context, dC is also the predominant nucleotide incorporated opposite 2＇-deoxy-5-hydroxyuridine (5-OHdU).

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