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Methapyrilene hydrochloride

CAS No. : 135-23-9

MCE 站：Methapyrilene hydrochloride

产品活性：Methapyrilene (Thenylpyramine) hydrochloride 是一种口服活性 H1 受体 (H1-receptor antihistamine) 抗组胺剂和吡啶类抗胆碱能剂。Methapyrilene hydrochloride 具有肝毒性，可作为肝毒素在体内引起门脉周围肝坏死。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Methapyrilene hydrochloride (650 μM) results in a down-regulation of TF ａnd up-regulation of FTL, while the level of HMOX1 is not changed. Additionally, the levels of CD44 ａnd SOX9 proteins ａnd the expression of PROM1 (CD133), hepatic stem cell-associated markers are increased.
Methapyrilene hydrochloride (650 μM) decreases CYP2E1, CYP3A4, NR1l3, ALB, mRNA expression ａnd increases CD133 expression.

In Vivo: Methapyrilene hydrochloride (oral gavage; 40 or 80 mg/kg; 5 days per week; 6 weeks) results in changes in the expression of classic hepatotoxicity-related marker genes ａnd iron homeostasis-related genes, especially a prominent, dose-dependent down-regulation of the transferrin (Tf) gene ａnd an up-regulation of the ferritin, light chain (FTL) gene in rats.
Methapyrilene hydrochloride (oral gavage; 150 mg/kg; 3 days) causes periportal liver necrosis at high dosage. Methapyrilene is sufficient to induce liver necrosis, or a subtoxic dose of 50 mg/kg/day.

相关产品：Histamine  |  Clemastine fumarate  |  Terfenadine  |  Astemizole  |  Amitriptyline hydrochloride  |  Fexofenadine hydrochloride  |  Osthole  |  Famotidine  |  Levocetirizine dihydrochloride  |  Diphenhydramine hydrochloride  |  Perphenazine  |  Loratadine  |  Cimetidine  |  Lodoxamide  |  Pitolisant hydrochloride  |  Chlorprothixene  |  Desloratadine  |  Latrepirdine dihydrochloride  |  Rupatadine Fumarate  |  Mianserin hydrochloride  |  Mirtazapine  |  Ritanserin  |  Ebastine  |  Azelastine hydrochloride  |  Chlorpheniramine maleate  |  Adriforant hydrochloride  |  Mepyramine maleate  |  Ranitidine hydrochloride  |  Bavisant dihydrochloride hydrate

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