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5＇-N-Ethylcarboxamidoadenosine

CAS No. : 35920-39-9

MCE 站：5＇-N-Ethylcarboxamidoadenosine

产品活性：5＇-N-Ethylcarboxamidoadenosine (NECA) 是一个非选择性的腺苷受体激动剂。

研究领域：GPCR/G Protein

作用靶点：Adenosine Receptor

In Vivo: After the administration of 5＇-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5＇-N-Ethylcarboxamidoadenosine (NECA): F(4,12)=14.9; P<0.001]. The administration of 5＇-N-Ethylcarboxamidoadenosine (NECA) [F(4,12)=16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment. Daily i.p. injection of 5＇-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α ａnd interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5＇-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats.

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