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MitoTam bromide, hydrobromide

CAS No. : 1634624-73-9

MCE 站：MitoTam bromide, hydrobromide

产品活性：MitoTam bromide, hydrobromide 他莫昔芬衍生物，它是一种电子传递链 (ETC) 抑制剂，抑制衰老细胞中的线粒体膜电位变化并影响线粒体形态。MitoTam bromide, hydrobromide 是一种有效的抗癌剂，可以抑制乳腺癌细胞中呼吸复合物 (CI-respiration) 和超复合物 (SCs) 的形成。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Mitochondrial Metabolism

In Vitro: MitoTam (0.5 μM-56 μM; 24 hours) kills breast cancer cell Lines ａnd nonmalignant cells with an IC₅₀ range from 0.65 μM to 55.9 μM.
MitoTam (2.5 μM; 2-24 hours) results in stronger activation of the apoptotic pathway in MCF7 Her2 high cells compared with mock MCF7 cells.
MitoTam (0.05 μM-1 μM; 3 days) causes a concentration-dependent induction of apoptosis in breast cancer cells, while there was no effect for non-malignant breast epithelial cells

In Vivo: MitoTam (intraperitoneal injection; 2 μg/g; once a week; 4 weeks) decreases β-gal staining of lungs from MitoTam-treated mice, accompaning by a inhibition in the expression of senescence markers p16Ink4a, p21waf1 ａnd PAI comparing control mice sup>[2].
MitoTam (intraperitoneal injection; 0.54 μmol/mouse; twice a week; 2 weeks) inhibits growth of syngeneic tumors by 80%.
MitoTam (intraperitoneal injection; 0.25 μmol/mouse; twice a week; 2 weeks) slows down the growth of MCF7 mock tumors ａnd stops tumor progression after two doses; suppresses Her2^high carcinomas decreased threefold from the original size with complete disappearance.

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