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(R)-Posenacaftor sodium

CAS No. : 2095064-09-6

MCE 站：(R)-Posenacaftor sodium

产品活性：(R)-Posenacaftor (R)-PTI-801) sodium 是 Posenacaftor 的 R 对映异构体。Posenacaftor (PTI-801) 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂，可纠正 CFTR 蛋白的折叠和运输。Posenacaftor 用于囊性纤维化 (CF) 的研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：CFTR

In Vitro: Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective ａnd misfolded CFTR protein, ａnd impairs the flow of ions in ａnd out of cells.
Posenacaftor is a CFTR corrector, correctors are designed to fix ａnd restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel ａnd helps maintain the right balance of fluid in the airways.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Covalent Screening Library  |  Lumacaftor  |  Elexacaftor  |  Glibenclamide  |  Ivacaftor  |  Tezacaftor  |  CFTR(inh)-172  |  Ataluren  |  PTI-428  |  (R)-BPO-27  |  GLPG1837  |  GLPG2451  |  GlyH-101  |  IOWH-032  |  PPQ-102  |  CFTR corrector 2  |  KM11060  |  Icenticaftor  |  Posenacaftor sodium  |  CFTR corrector 4  |  CFTR corrector 6  |  Crinecerfont  |  GLPG-3221  |  K41498 TFA  |  Kobusin  |  PG01

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